Accelerate the development of broad and ultra-potent anti-HIV-1 antibodies through licensing or direct investment.
These novel anti-HIV-1 antibodies are broader and more potent than a majority of anti-HIV-1 human broadly neutralising antibodies and present an opportunity for a platform technology for rapid discovery and testing of therapeutic antibodies.
Using ten novel anti-HIV-1 antibodies, immunotherapy has the potential to suppress infection and increase the rate of clearance of infected cells.
There are no means to cure or prevent HIV infection. Approximately 38.4 million people were living with HIV at the end of 2021, with an estimated 1.5 million people per year becoming newly infected globally. Anti-retroviral therapy is a lifelong treatment which requires diligent adherence and can be associated with toxicity and significant economic costs.
The novel anti-HIV-1 antibodies demonstrate superior breadth and potency in comparison to clinical stage antibodies. Further preclinical evaluation is currently underway. There is also an opportunity for a platform technology for rapid discovery and testing of therapeutic antibodies.
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