Frequently Asked Questions (FAQs)

For the analytical systems, there is no specific limit on how many samples you can run other than those imposed by sample capacity of the instrumentation and how many other users need time. You cannot run your samples in preference or to the exclusion of anyone else.  You have to share. However, if the machine is free you can use it non-stop.  We want the machines running 24/7.  They cost almost the same if they are working or not so we may as well run them as much as possible.

For the “Omics” systems (proteomics and lipidomics) the subscription cost covers up to 500 samples before you become a “super-user”.  At that point you will need to pay a second subscription, etc.

We recommend that users of the analytical systems (eg QQQ systems or HPLC users) have their own columns although there are some general-use columns available at own risk. We generally cover solvent costs for the instruments with the exception of the prep-HPLC systems (the large volume means you need to cover this).

For Proteomics and lipidomics we cover the machine time and nano-columns but you will need to pay for reagents needed for the sample prep (like trypsin, TCEP, TEAB Buffer, S-traps, TMT reagents, lipid splash mix, etc). We can advise users on what to buy during training.  On some occasions users may need to pay for nano-trap columns depending on sample prep.

Yes. But we do not normally work that way. We usually find that one or two samples inevitably turn into 4 or 5 samples plus controls and multiple replicates. Also, a simple mistake or modification can also mean you need to repeat the entire process. By that time, you may as well have paid the 3-month cost and done as many controls and repeats as you like.

We can, but generally this is not how we work. We would have to provide a project quote and it will be much more expensive. There are plenty of other proteomic and mass spectrometry facilities around that can do this sort of thing.

Yes and no, depending on what you are doing.

For the simple analytical machines, YES, we teach you how to run the instruments. It's very easy to analyse the mass of a single peptide or chemical product. We have more than 60 people who routinely use the Agilent QTOF to do quality control on their recombinant proteins. More than 100 use the chemistry Orbitrap to test their organic synthesis or peptide synthesis. It's not hard at all.

For Proteomics and Lipidomics, the instrumentation is more complex and so you prepare the samples, but we run the machines for you. Most people don’t have the time or interest to learn how to get the most from these machines. If you want to know how the machine works, then we can explain, but most people do not care. We have a sample queue and we send you a message to let you know when to bring the samples to us. Once complete, our computer system will automatically send you the data when its done.

Yes. The only difference is that external academics pay more for the same thing – which is still an absurdly low price.

Yes. Industry groups are welcome and we have a number of current industry clients. The cost depends on what is required. For more details, contact us.

Yes. This is our primary purpose. Our staff are often part of PhD committees and we often co-supervise students.

Yes. Our staff are involved in many projects and we are often included as AIs or CIs on grant proposals. We can help with grant writing where required.