From a PhD to a mobile app that helps predict seizures

 

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Life after graduate research: Dr Pip Karoly

During her PhD, Dr Pip Karoly noticed new cycles for seizures in epilepsy sufferers – including weekly, monthly and even longer cycles. Since then, she’s learnt to code and has developed a seizure tracking and forecasting app – a concept she outlined during her PhD.

Pip Karoly is a white woman with a bright smile and medium-length brown hair

In what area of research was your PhD?

Clinically applied neuroscience.

What were you trying to discover in your PhD?

I was working in a team that was trying to develop new methods for predicting seizures for people with epilepsy. I was lucky because I had access to existing data sets for analysis. I used a long-term data set of brain implant recordings from a human clinical trial in Melbourne. And a large set of mobile seizure diaries from some collaborators in the USA.

In some cases, we had thousands of seizures per person. With that information, we developed models that would determine seizure likelihood based on certain factors. The way that a weather forecast predicts the chance of rain.

Previously, we and other researchers had wanted to predict seizures in a definitive fashion. During this time, however, we shifted our thinking as a team. We became focused on providing a good estimation of seizure probabilities, rather than certain outcomes.

A really pivotal point in my PhD research was when I asked if we could translate what we were seeing from a brain implant, a very invasive device, to a wearable device.  And we could!

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What were the main findings of your PhD?

One of the big discoveries we made was that we noticed new cycles for seizures in individuals. We’ve known for a long time that circadian cycles correlate with seizures. But we didn’t know how prevalent longer cycles are too. We noticed weekly, monthly and even longer cycles in individuals. This was fascinating and we needed the large data sets to realise this. Why these cycles exist still remains somewhat of a mystery.

I also included in my report a proof of concept for a seizure tracking and forecasting app. This is what I am working on now.

Why did you do a PhD?

My interest in this area was sparked by my final-year masters Endeavour project here at the University of Melbourne. In these projects, students work in collaboration with government and industry to solve real-world challenges.

Our Endeavour project measured brain activity to convert someone’s intentions into movement of a cursor on a screen, known as a brain-machine interface. It was a really fun and interesting project. And the people I worked with were also working in epilepsy research.

They’d led a brain implantation device trial. And that trial created the data I used for my PhD. So, through Endeavour I met the people who became my supervisors in that final-year project.

Why did you choose to do your PhD at the University of Melbourne?

After my masters, I worked for a year as a research assistant with the people I’d met through the Endeavour project. It was fantastic preparation before diving into my PhD.

Through working as a research assistant, I connected with international researchers and industry professionals. And I knew I wanted to continue to be part of that network, so I didn’t really consider doing my PhD anywhere else.

What was the best part about researching here?

I got to work with world-renowned researchers in and outside of the University. I wouldn’t have made the same contacts at another university.

I also went to the USA for 10 months to continue my research at the University of Pennsylvania. This came about because one of my supervisors, Professor Mark Cook, is connected with a neurologist there. It wasn’t a formal exchange, but they sponsored my visa, nonetheless.

I also got some additional funding through a University scholarship. That’s another thing – you can apply for scholarship top-ups through the University of Melbourne for research-related travel.

Dr Pip Karoly Workshop

How has your PhD shaped your current work situation?

Just before I completed my PhD, some of my colleagues (Dr Dean Freestone, Professor Cook and George Kenley) co-founded the epilepsy diagnostic company Seer Medical. And I was on board with them from the start, working towards the design of a seizure forecasting app that I outlined in my PhD. My experience with the mobile software team and developing a commercial app has shaped my research career today.

I am now a Research Theme Lead of the Rhythms in Physiology Lab (RiPL) based at The Graeme Clark Institute, at The University, and continue work with industry from wearable devices to brain implants that are pursuing clinical translation of seizure forecasting. Our vision at RiPL is unravelling mechanisms of multiday cycles in the brain, heart and body, to inform personalised disease management and optimise health.

While my PhD research found multiday cycles were common for people with epilepsy, we now know these multiday rhythms are more widespread, affecting other systems, like the heart. I’m excited to now be working with new clinical partners from genetics to cardiology to explore some of these novel applications.

In 2022 our breakthrough technology to track seizure risk was awarded a Prime Minister’s Prize for New Innovators. That recognition drew national attention to the uncertainty of living with seizures and unlocked new commercial partnerships for our forecasting technology, including internationally. I’m now involved in a new MedTech start-up that aims to unify our research discoveries using mobile and wearable devices to better manage seizures and other neurological disorders.

Team Dr Pip Karoly

What do you wish you’d known before you started your research?

It is such a unique time as you get to have a single-minded focus on something. While it’s challenging, you want to make time to really enjoy that experience. Now that my PhD is over, I’m involved in lots of different activities again which can feel overwhelming.

The opportunity to focus on one specific problem doesn’t come around that often. I underestimated how much I would miss it once it was over.

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First published on 9 August 2024.

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