
Understanding how colorectal cancer resists treatment by studying netrin-1
This research project will study how the protein netrin-1 helps colorectal cancer cells resist therapy.
This project examines the potentially harmful effects of volatile silicon compounds. They are found in personal care products and are spread to humans and the environment.
This project aims to answer the following questions:
This project aims to investigate the atmospheric chemistry of the volatile silicon compounds present in personal care products. Daily use of products such as shampoos, deodorants and lotions releases these compounds into the air. As personal care products are mainly kept indoors, it is important to understand how volatile silicon compounds affect indoor air quality and if they affect our health.
The project has a theoretical component and an experimental component. The theoretical component will involve computational chemistry tools and statistical reaction rate theory modelling. Some of this work will require the use of high-performance computing systems through Research Computing Services. The experimental component will involve spectroscopic techniques like fluorescence assay by gas expansion (FAGE) and continuous wave cavity ring down spectroscopy (cw-CRDS). These techniques will be performed at the University of Lille.
What did you do before you started your PhD?
Before I started my PhD, I obtained a Bachelor of Science degree in biochemistry from the Vietnam National University of Ho Chi Minh City (International University). I then continued working as a research assistant at the university after graduation. I have been working on the development of a theoretical kinetic model for biofuel-related chemical reactions since my undergraduate degree. This experience ultimately sparked my interest in reaction kinetics. I’m especially interested in how reaction kinetics can be applied to improve both the environment and human health.
What are the challenges of your research role?
As a joint PhD candidate, I had to adjust to the culture, formalities and research conventions of two universities. I also had to figure out how to stay connected and communicate effectively with two different research groups. Because my project is a combination of theory and practical experiments, I have to understand both elements really well and integrate them to answer the main research questions.
What is the best part of your research role?
The best part of my research role is being able to meet and work alongside researchers from the University of Melbourne, the University of Lille and the broader Melbourne-CNRS Network.
Where do you wish to go after your PhD? Do you want to enter industry or continue doing more research?
After my PhD, I want to work in academia in a chemistry-related role. I am interested in teaching, and also wish to continue doing research on environmental and health issues.
University of Melbourne: Dr Gabriel da Silva
CNRS: Dr Christa Fittschen
This research project will study how the protein netrin-1 helps colorectal cancer cells resist therapy.
This research project examines the role of tissue mechanics in regulating seed growth.
This research project aims to investigate human-river interactions in urban areas.
This research project aims to characterise p97, an ATPase with essential roles in many cellular processes.