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University of Melbourne researchers have created star-shaped polypeptides. These are Structurally Nanoengineered Antimicrobial Peptide Polymers, or SNAPPs. They have anti-bacterial properties, including against MDR bacteria.
SNAPPs also have adjuvant activity, improving the efficiency of existing antibiotics.
Multi-drug resistant (MDR) bacteria are a threat to human health. The development of novel anti-bacterial therapies is a global health priority.
Proof-of-concept has been achieved using various in vitro microscopy and bioassay studies. These show SNAPPs’ antimicrobial activity, mode of action and low toxicity.
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Image by Medical Illustrator Alissa Eckert. Photo by US Centers for Disease Control and Prevention (CDC) on Unsplash.