The Melbourne Protein Characterisation platform offers technology for identifying the characteristics of individual proteins, including their size, structure and physiochemical properties.
The platform incorporates part of the Australian Cancer Research Foundation (ACRF) Facility for Innovative Cancer Drug Discovery and forms part of the drug discovery pipeline that connects the Bio21 platforms together. Additionally, the Bio21-WEHI Crystallization Facility was established in 2023 as part of the MPC platform.
The platform supports protein discovery research across a range of experiments and procedures. These include experiments to understand the function and behaviour of molecular interaction and structural analyses.
We offer training and advice, and can help researchers with:
- Peptide synthesis and protein production (for insect and mammal cells)
- Studying molecular binding and interactions
- Analysing oligomerisation and association states
- Determining protein size, shape and secondary structure
- Studying heterogeneity and aggregation
- Analysing fluorescence and UV absorbance
- Detecting small molecule binding
- Analysing X-ray diffraction-based structure for small molecules and proteins
- Crystal screening and imaging
Resources
Protein production
- Peptide synthesizer
- Sarto Flow
Protein interaction
- Mass photometer
- Analytical ultracentrifuges
- Isothermal titration calorimeters
- Circular dichroism spectrometers
- Dynamic light scattering - Zetasizer
- Differential scanning calorimeter
- Surface plasmon resonance - Biacore
- 18 angles light scattering system
X-ray diffraction
- X-ray diffractometer - Rigaku Synergy-S
Crystallisation
- NT 8 Robots
- Rock Imager
User information
The platform is open access to all researchers for both academic and industry use. We offer training and fee-for-service options.
More information about the platform
Other platforms
The platform can be used in conjunction with:
- Bio21 Ian Holmes Imaging Centre
- Mass Spectrometry and Proteomics facility
- Melbourne Magnetic Resonance
Contact us
- Yan Hong Tan
- yan.tan@unimelb.edu.au
- Phone
- +61 3 9035 3858
Book online using iLab
You can book this resource or platform using the iLab booking system. You will need to create an account before logging in. Access user guides and videos to help you set up an account and navigate the iLab system:
More information on this platform can be found on the Research Gateway, which is available to all University of Melbourne academic and honorary staff, graduate researchers and professional staff. Please note, to access the Research Gateway, you will need to login with your University of Melbourne username and password.
Banner image: A woman behind an x-ray Diffractometer machine. Image by Peter Casamento.