
How to apply
Apply for a joint PhD with the Toronto-Melbourne Research Training Group.
Drug resistance in patients with acute myeloid leukemia (AML) is a major hurdle for successful therapy.
MicroRNA (miRNA) are small RNA with critical roles in most cellular processes that can promote diverse diseases when disrupted. Aberrant miRNA expression has been implicated in the development and maintenance of AML, however little is known about the specific role and clinical utility for miRNA in AML chemoresistance.
Collectively, the Salmena and Kats labs have developed advanced cellular and molecular tools, novel bioinformatic approaches and have access to mouse models of leukemia and human samples that will allow the identification and validation of miRNA that are critical for chemoresistance.
The efforts outlined in this project represent fundamental work required to identify novel microRNA-associated therapeutic strategies to improve treatments for AML.
The goal of this project is to:
The University of Melbourne: Dr Lev Kats
*Click on the researcher’s name above to learn more about their publication and grant successes
The University of Toronto: Associate Professor Leonardo Salmena
We are seeking a PhD candidate with the following skills:
The PhD candidate will benefit from the combined expertise of the project supervisors, and the embedding into two research environments.
Dr Lev Kats at the University of Melbourne will contribute their expertise in mouse models and anlaysis of drug resistance mechanisms. Associate Professor Leonardo Salmena at the University of Toronto will contribute expertise in miRNA biology and functional genomics.
This PhD project will be based at the University of Toronto with a minimum 12-month stay at the University of Melbourne.
The candidate will be enrolled in the PhD program at the Department of Pharmacology & Toxicology at the University of Toronto, and in the PhD program at the Sir Peter MacCallum Department of Oncology at the University of Melbourne.
To apply for this joint PhD opportunity, and to view the entry requirements, visit How to apply.
Apply for a joint PhD with the Toronto-Melbourne Research Training Group.
Discover what researchers from the Toronto-Melbourne Research Training Group are working on right now.
Hear the stories of current and past graduate researchers. Find out about their experiences at the University and where their degrees have taken them.
Find a supervisor at the University of Melbourne