
Understanding land and river degradation in urban areas
This research project aims to investigate human-river interactions in urban areas.
The ATPase p97 has essential roles in many cellular processes. A better understanding of its different structures could reveal more about these functions.
The goals of this research project are to:
ATPases are enzymes that use the energy released from ATP hydrolysis to perform other functions in the cell. The ATPase p97 uses this energy to remove other proteins from large complexes or assemblies. This function is an important part of many cellular processes.
Analysis using single-particle cryo-electron microscopy shows that p97 exists in different conformations. The protein interacts with up to 20 cofactors, which target its function to different pathways in the cell. But the spatial and dynamic properties of these interactions remain unknown.
This project aims to characterise these properties and the p97 conformational landscape. This knowledge will be vital to understanding the protein’s functional mechanisms.
The University of Melbourne: Associate Professor Isabelle Rouiller
CNRS, Sorbonne Université: Dr Slavica Jonic
This research project aims to investigate human-river interactions in urban areas.
This research project examines the role of tissue mechanics in regulating seed growth.
This research project will study how the protein netrin-1 helps colorectal cancer cells resist therapy.
This research project examines the effect of volatile silicon compounds on indoor air quality.