MIG Seminar Series - Doug Speed - Better understanding the genetic architecture of complex traits from summary statistics

Seminar/Forum

MIG Seminar Series - Doug Speed - Better understanding the genetic architecture of complex traits from summary statistics

Better understanding the genetic architecture of complex traits from summary statistics

We have recently developed SumHer, software for analysing summary statistics from genome-wide association studies (GWAS). By applying SumHer to data from 24 large-scale studies (average sample size 121,000), we show that GWAS have tended to over-correct for confounding, and as a result under-reported the number of causal associations by about a quarter. We show that on average, SumHer estimates of SNP heritability are about twice those from LD Score Regression, while SumHer also gives much more modest estimates of heritability enrichments. By using the results of SumHer we can improve prediction of complex traits, and also construct a bespoke genome-wide significant threshold level, which takes into account that some SNPs are more important than others.

Presenter

  • Dr Doug Speed
    Dr Doug Speed, Assistant Professor, Aarhus Institute of Advanced Studies, Aarhus University, Denmark