CBRI Seminar – Sarah Medland – 22nd July 2016
Imaging Genetics: Computational Challenges and Lessons Learned
At the individual level, there is substantial variation in brain structure morphology and brain functions. To identify robust and replicable associations with genetic variants or psychiatric conditions large well-powered studies are required. Due to the substantial costs associated with imaging studies collaborative research strategies are becoming increasingly important. Within the context of the ENIGMA Consortium, we conduct collaborative large-scale genetic analysis of MRI scans. Our work focuses both on the discovery of genetic variants that exert lasting influences on brain structure and function and on the identification of disease correlates. Our recent findings will be discussed focusing on genetic variants influencing the morphology of subcortical and cortical structures.
Sarah is a statistical geneticist working on mental health and neurological traits. She received her PhD in 2006 in Psychology from the University of Queensland. Sarah completed a Sidney Sax NHMRC Post-doctoral Fellowship in the United States at the Virginia Institute of Psychiatric and Behavioral Genetics. She was awarded an ARC Future Fellowship in 2012 and an NHMRC Senior Research Fellowship in 2016. As chair of the genetics team of ENIGMA neuro-imaging genetics consortium, she has played a leading role in large multi-site studies identifying genetic variants influencing brain structure in healthy and disease-focused cohorts.