CBRI Seminar – Sebastián Duchêne – 6th May, 2016
A seminar by Dr Sebastián Duchêne (Charles Perkins Centre, University of Sydney)
Reconstructing pathogen evolution using phylogenetic methods
Recent advances in sequencing technologies have dramatically increased the amount of available molecular data. Phylogenetic methods use statistical models to take advantage of these data to reconstruct the evolutionary history of organisms. For example, in the context of infectious diseases such methods allow inferences of time of origin, spread, and transmission rates. Typically, the reliability of these inferences is determined by comparing the statistical fit of a set of evolutionary models. However, this approach only informs about relative, but not absolute, model performance. As a result, it is impossible to determine the extent to which the inferences are accurate. In this talk, I will present an array of alternative approaches which assess the absolute performance of evolutionary models. Such assessments will allow us to improve the reliability of inferences made using current methods as well as develop more realistic models, thereby increasing the amount of information gained from genomic data sets.
When: 11am, Friday 6 May
Where: ESJ King Theatre
Level 3, Medical Building
University of Melbourne, Parkville
No registration required - all welcome. Please direct enquiries to Andrew Siebel.