OREI Keynote: 10% of the time it works every time (or recognizing sloppy science)

Abstract:  As scientists and physicians we all want to make discoveries that will substantially impact human health. We know that scientific advance is predicated on new knowledge that is robust and reliable, and that serves as a foundation on which further advances can be built.

Biomedical research is in the midst of a revolution with the generation of new data and scientific publications at a previously unprecedented rate. However, unfortunately, there is compelling evidence that the majority of these discoveries will not stand the test of time. This lack of solid, trustworthy data is a multifaceted, multi-stakeholder problem - no single party is solely responsible, and no single solution will suffice. Examples of the recurring lack of attention to scientific rigor and reproducibility will be provided, and potential solutions will be discussed.

About C. Glenn Begley

Dr C. Glenn Begley graduated from the University of Melbourne with M.B., B.S. degrees in 1978, and completed his training at the Royal Melbourne Hospital and the Walter and Eliza Hall Institute of Medical Research.  He is Board Certified in Australia as a Medical Oncologist and Hematologist (F.R.A.C.P.) and has a Ph.D. in cellular biology from the University of Melbourne. He is currently Chief Scientific Officer and Senior Vice-President Research & Development at TetraLogic Pharmaceutical Corporation, Malvern PA, USA and Non-Executive Director, Oxford BioTherapeutics, UK. He also serves on the Scientific Advisory Board for a number of biotech companies. From 2002 to 2012, he was Vice-President and Global Head of Hematology and Oncology Research at the California-based biotech company, Amgen.

He has over 20 years of clinical experience in medical oncology and hematology. His research has focused on translational clinical trials and regulation of hematopoietic cells.  Recently he has highlighted the need for reproducibility in science.

He has received numerous honors and awards, including being elected as the first Foreign Fellow to the American Society of Clinical Investigation in 2000, and to the prestigious Association of American Physicians in 2008. In 2014 he was an inaugural inductee into the "Hall of Fame" at the Royal Melbourne Hospital, and elected to the Australian Academy of Health and Medical Sciences.